From a comment at:
http://www.scientificamerican.com/article/c-elegans-connectome/
Blue Brain Project conducted by Henry Markram is attempting to do it. Cognitive Computing leaded by ibmer Dharmendra Modha is also trying it.
However, nobody (as far as I know) has ever try to simulate C. Elegans nervous system. ¿Why?
To my understanding there must be enormous advantages in achieving it. First in test computer simulations. Second in understanding C. Elegans behavior.
That seems like a significant comment. Why indeed would there be efforts to go to bigger brains when the c. Elegans connectome provides a way to develop simulations as theories of how the connectome works.
That is, linear system model could be matched to titration levels of specific proteins as its state. Evan that simple model could provide rough model structuring, to be refined with more logical distinctions among situations as they are cataloged.
Has anyone heard of such a simulation project on C. Elegans?
-Rich
Sincerely,
Rich Cooper
EnglishLogicKernel.com
Rich AT EnglishLogicKernel DOT com
9 4 9 \ 5 2 5 - 5 7 1 2
-----Original Message-----
From: ontolog-forum-bounces@xxxxxxxxxxxxxxxx [mailto:ontolog-forum-bounces@xxxxxxxxxxxxxxxx] On Behalf Of John F Sowa
Sent: Monday, November 24, 2014 7:30 PM
To: ontolog-forum@xxxxxxxxxxxxxxxx
Subject: Re: [ontolog-forum] Sabotaging a communication system is not a new idea
On 11/17/2014 10:05 PM, Rich Cooper wrote:
> There is an intriguing paper in PNAS on the teensy 302 neurons
> in the worm C. Elegans
Following is an article from the _Scientific American_,
which gives a more general overview of the issues:
http://www.scientificamerican.com/article/c-elegans-connectome/
The Connectome Debate: Is Mapping the Mind of a Worm Worth It?
The two concluding paragraphs of that article:
> Because any brain or nervous system is so much more complex than
> what a connectome by itself represents, Movshon is certainly not
> alone in thinking that researchers' limited resources are better
> devoted to other areas of neuroscience. "I'm all in favor of Seung
> and others," Bargmann says, "but I don't think we should have a
> Manhattan Project for the connectome with such a huge amount of
> resources. We are not quite good enough at reading them. It wasn't
> like the human genome project, where we knew how to sequence DNA
> and said, 'Yeah, let's go for it!' Scaling up connectomes is a
> different issue."
>
> Oliver Hobert of Columbia, another longtime C. elegans researcher,
> agrees that connectomics only scratches the surface. "It's like a
> road map that tells you where cars can drive, but does not tell
> you when or where cars are actually driving," he says. "Still, > connectomics of C. elegans has given us wonderful testable hypotheses
> in terms of how neural circuits work. What we have learned from
> C. elegans diagrams are not just specific worm behaviors—they are
> logical principles common to much of biology."
John
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